Polycythemia Vera Terminating with Myeloblastic Leukemia

Polycythemia vera terminating with myeloblastic leukemia; correlation of morphologic findings with leukocytic phosphatase studies.

Polycythemia Vera Terminating in Refractory Ascites

A 64-year-old woman,with more than a 20 year history of polycythemia vera(PV),developed portal hypertension,myelofibrosis and extramedullary hematopoiesis accompanied by massive ascites. Portal hypertension resulted not only from infiltration of the liver sinusoids by hematopoietic cells but also from nodular regenerative hyperplasia of the liver. Wright-stained smears of ascites samples consis...

Preleukemia and leukemia in polycythemia vera.

A group of 76 polycythemia vera patients was followed prospectively with bone marrow examinations at regular intervals. Six terminated in acute leukemia, preceded by an indolent preleukemic phase succeeded by a very fulminant leukemia. At autopsy, all patients had extramedullary hematopoiesis. In one of them, only the bone marrow was leukemic, suggesting that it was the primary site of this tra...

Paroxysmal nocturnal hemoglobinuria terminating in acute myeloblastic leukemia.

Myeloproliferative Syndrome with Leukemia Preceding Polycythemia Vera : A Case Report

SSOCIATED PROLIFERATION of the various hematologic elements in the marrow, although recognized for some time,2 has recently been the subject of renewed interest.3’8 A close relationship between myelofibrosis and he leukoerythroblastic conditions was demonstrated by Vaughan and HarrisonT in 1939. They suggested that an unknown stimulus acting on the primitive mesenchymal reticulum cell may be re...